I use Simply3D with my Lulzbot TAZ 6 and am quite happy with that. I love the way supports can be totally customized, and, are relatively easy to remove from 3D prints. S3D’s preview window is outstanding.
I use Prusaslicer with my Prusa MK3s and like very much how well it is integrated as, what I would call, a turnkey system. The features equal and in some areas surpass Simplify3D except for ‘supports’ in my opinion.
One of these days I will make a Prusaslicer printer profile for the TAZ 6 and test it out. I have about 1.5 years experience with 3D printing (thanks to Shapr3D) and consider myself an intermediate+ user.
Now to answer your question- Personally, I would give a slight edge to Prusaslicer. I’m waiting to see what the paid upgrade for Simplfy3D has to offer, if and whenever it gets released.
BTW, love your teeth