Disable buttons while they’re not useful

Please follow the format below for requesting a feature.

The problem that this feature will solve:
Pretty often, I’ll click to deactivate Isolation mode while some tool is active, which prevents it from working. No error, just nothing happens when you click.

Brief description of the outcomes that you expect from this feature:
When clicking a button would do nothing, that button should be visibly disabled.

What can’t you achieve without this feature?
Satisfaction